We provide services customized to your target of interest that are biologically-relevant, MoA reflective, robust assays with high reproducibility in a high-throughput format to expedite your biologics screening process. A broad screening roadmap to ascertain the MoA and establish potency is described below:
Monoclonal antibodies
- Binding, internalization kinetics, ELISA, Flow cytometry
- Functional assays-ADCC, ADCP, CDC, cytotoxicity
Bispecifics and scFv
- Binding (for both T cell arm and tumor arm), Flow cytometry
- Bispecific mediated cytotoxicity assay, ADCC, ADCP
- T cell and target cell conjugation
CAR-T cells (in vitro PoC)
- T cell expansion (from PBMCs) and enrichment and transfection of T cells with CAR-T mRNA
- Cancer cell and CAR-T cell co-cultures: proliferation, cytokine, cancer cell killing
Translational studies
- Evaluation of molecules in patient derived explants, patient derived cell lines