- Method development and validation on HPLC/LC-MS/MS. Ability to achieve sensitivity upto picogram level.
- Bioanalytical support for GLP and regulated studies.
- Fit-for purpose method development for N-GLP analysis.
- Derivatization approach for poorly ionizable compounds.
- Quantitation of analyte/ metabolites indifferent matrices plasma, serum, blood etc.
- Method development in other matrices like urine, feces, bile, CSF, cell lysate and tissue homogenates.
- PD marker identification for small molecules (Target based approach).
- Development and validation of desired biomarkers for PK/PD
- Quantitation of marker compounds in plasma of animals administered with plant extract for PK parameter evaluation.
Metabolite Identification
- Metabolite generation using liver microsomes and plasma incubations
- Metabolite generation using protocols of metabolic stability in liver
- Microsomes and plasma stability at accelerated conditions
- Chromatographic optimization for separation of all metabolites